Lipopeptide antibiotics for XDR Gram-negative infections [ 2018 - ]

Research Grant

Researchers: Dr Mark Blaskovich (Principal investigator) ,  Dr Karl Hansford ,  Prof David Paterson ,  Prof Jason Roberts ,  Prof Matthew Cooper

Brief description The polymyxins are a drug class considered to be a last-resort treatment option for multidrug-resistant (MDR) and extremely drug resistant (XDR) Gram-negative infections. Unfortunately resistance is rapidly developing against these antibiotics, leaving no effective therapies and resulting in patient death. This project aims to develop an antibiotic with superior spectra of action and improved safety profiles compared to the polymyxins, with activity against polymyxin-resistant bacteria.

Funding Amount $994,897.00

Funding Scheme Development Grants

Notes Development Grant