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Lipidomic dataset of plasma from patients infected with wild type and nef-deficient HIV-1 strain

RMIT University, Australia
Professor Melissa Churchill (Aggregated by, Associated with)
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ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rfr_id=info%3Asid%2FANDS&rft_id=info:doi10.1016/j.dib.2015.11.067&rft.title=Lipidomic dataset of plasma from patients infected with wild type and nef-deficient HIV-1 strain&rft.identifier=749a13bbba097dadefa4ea65bdbb6421&rft.publisher=RMIT University, Australia&rft.description=Previous in vitro and in vivo studies demonstrated that HIV protein nef plays a key role in impairing cellular and systemic cholesterol metabolism in HIV disease, but clinical support for these findings is lacking. Here we present the data of comparative lipidomic analysis (330 lipid species) of plasma samples from HIV-negative subjects, patients infected with WT HIV-1 strain and patients infected with nef-deficient strain of HIV-1. We determine which effects of HIV on plasma lipidome are explained by the presence of nef. The data can be used to evaluate cardiovascular risk in HIV disease and to assess the role of nef in HIV-induced disturbances in systemic lipid metabolism. The full impact of nef deficiency on lipid and lipoprotein metabolism in HIV-infected patients is presented in the accompanying study Lipid Metabolism in Patients Infected with Nef-deficient HIV-1 Strain&rft.creator=Professor Melissa Churchill&rft.date=2018&rft.relation=https://dx.doi.org/10.1016/j.dib.2015.11.067&rft_rights=All rights reserved&rft_rights=CC BY-NC: Attribution-Noncommercial 3.0 AU http://creativecommons.org/licenses/by-nc/3.0/au&rft_subject=Lipids&rft_subject=nef Gene Products&rft_subject=Human Immunodeficiency Virus&rft_subject=nef protein&rft_subject=Human immunodeficiency virus 1&rft_subject=RNA&rft_subject=Viral&rft_subject=Virology&rft_subject=BIOLOGICAL SCIENCES&rft_subject=MICROBIOLOGY&rft.type=dataset&rft.language=English Access the data
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Previous in vitro and in vivo studies demonstrated that HIV protein nef plays a key role in impairing cellular and systemic cholesterol metabolism in HIV disease, but clinical support for these findings is lacking. Here we present the data of comparative lipidomic analysis (330 lipid species) of plasma samples from HIV-negative subjects, patients infected with WT HIV-1 strain and patients infected with nef-deficient strain of HIV-1. We determine which effects of HIV on plasma lipidome are explained by the presence of nef. The data can be used to evaluate cardiovascular risk in HIV disease and to assess the role of nef in HIV-induced disturbances in systemic lipid metabolism. The full impact of nef deficiency on lipid and lipoprotein metabolism in HIV-infected patients is presented in the accompanying study "Lipid Metabolism in Patients Infected with Nef-deficient HIV-1 Strain"

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Biological Sciences | Human Immunodeficiency Virus | Human immunodeficiency virus 1 | Lipids | Microbiology | RNA | Viral | Virology | nef Gene Products | nef protein |

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  • Local : 749a13bbba097dadefa4ea65bdbb6421
ACN 633 798 857