Research Grant
[Cite as https://purl.org/au-research/grants/arc/LP150100087]Researchers: Professor Esteban Marcellin Saldana (Chief Investigator) , Professor Lars Nielsen (Chief Investigator) , Dr George Moutafis (Partner Investigator)
Brief description Improving clostridial toxoid production through molecular fermentation maps. This project aims to improve vaccine production by generating detailed molecular maps of fermentation which will be used to design superior fermentation processes with reduced cost. Toxoid vaccines, used routinely in the livestock industry to prevent animal-disease caused by pathogenic Clostridia, are produced using batch fermentation processes. These processes have undergone limited optimisation over the past five decades. Low titres and frequent batch failures greatly affect capital use and represent a significant cost. In addition, current optimisation approaches are limited by the use of expensive and noisy endpoint assays. This project aims to use high-throughput chemistry (multi-omics) that overcome these limitations.
Funding Amount $488,000
Funding Scheme Linkage Projects
- PURL : https://purl.org/au-research/grants/arc/LP150100087
- ARC : LP150100087