[Cite as http://purl.org/au-research/grants/arc/LP130100517]
Researchers Dr Dayong Jin; Prof Nicolle Packer; Prof James Piper; A/Prof Robert Willows; Prof Simon Foote; Dr Bradley Walsh; Mrs Valentina Dubljevic;
Brief description Ten cancer cells need to be found in 10 ml of blood to be useful for diagnosis of the disease. Current industry-standard protocols are not sensitive enough to detect the many newly discovered cancer biomarkers that can differentiate these very low abundance abnormal cells from normal cells. We have developed nanocrystals that have more than three orders of magnitude greater sensitivity than the commercially available quantum dots. The attachment of these “superdots” to molecules will target specific, low frequency biomarkers and enable background-free imaging. We will specifically engineer next generation microscopy and flow cytometric devices to localise and isolate these low abundance molecules for the hypersensitive detection of disease.
Funding Amount 427510
Funding Scheme Linkage Projects