Linkage Infrastructure, Equipment and Facilities - Grant ID: LE180100179 [ 2018-03-29 - 2019-12-31 ]

Research Grant

Researchers: Alex de Marco (Chief Investigator) ,  Associate Professor Michael Landsberg (Chief Investigator) ,  Bostjan Kobe (Chief Investigator) ,  Derek Richard (Chief Investigator) ,  Dimitri Perrin (Chief Investigator)
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Brief description Automated high resolution and high contrast cryo -TEM for three-dimensional structural biology. This project aims to establish a facility in automated, single-particle cryo-TEM and cryo-TEM tomography (Titan Krios) that will enable atomic and molecular structure research and three-dimensional subcellular and cellular imaging. The project will span all multiscale cryo-TEM modalities from the visualisation of cells, membranes and macromolecular complexes, through to near-atomic-resolution protein structure determination. Cryo-single particle analysis and tomography are recognised as revolutionary technologies in molecular structural biology and powerful enablers of future ground-breaking discovery. The project will deliver significant competitive advantage for Australia in leading-edge structure-based research, drug discovery, new opportunities for applied research and development, and showcasing science to the public.

Funding Amount $3,189,000

Funding Scheme Linkage Infrastructure, Equipment and Facilities

View this grant in the ARC Data Portal