LINEs of Mutagenesis, Selection and Evolution in Ovarian Cancer and Chemoresistance [ 2017 - 2020 ]

Research Grant

Researchers: Dr Kyle Upton (Principal investigator)

Brief description L1 elements are powerful mutagens encoded within the human genome that becomes active in epithelial tumours. I will define the broad effects of L1 elements on the evolution of chemoresistance, focusing on ovarian cancer as a model system. Ovarian cancer is characterised by a poor 5 year survival rate of ~40% with most tumours developing resistance. Understanding the impacts of L1 on this evolution will inform the development and selection of more effective treatments for ovarian cancer.

Funding Amount $AUD 435,524.18

Funding Scheme Career Development Fellowships

Notes RD Wright Biomedical CDF