Leveraging genomics strategies to generate adult neurons from iPSCs and somatic cells [ 2017 - ]

Research Grant

Researchers: Prof Ryan Lister (Principal investigator) ,  A/Pr Julian Heng ,  Prof Ernst Wolvetang ,  Prof Jose Polo

Brief description Recent advances have made it possible to derive myriad specialized human cells from stem cells or by directly reprogramming cell identity. However, these derived cells are generally arrested at a fetal developmental stage, and do not mature to function like adult cells. We will use new genomic, epigenetic, cell reprogramming, and manipulation methods to discover how to derive mature cells, aiming to generate mature neurons for use in neurobiology research, disease modeling, and drug screening.

Funding Amount $1,593,336.00

Funding Scheme Project Grants

Notes Standard Project Grant