Leucocyte & Endthelial Cell Biology [ 2005 - 2009 ]

Research Grant

Researchers: Prof Mathew Vadas (Principal investigator) ,  Prof Angel Lopez ,  Prof Gregory Goodall ,  Prof Jennifer Gamble

Brief description The foot soldiers of the immune system, the white blood cells, constantly march through the body seeking out invaders, but kept in check by the barrier of endothelial cells that lines the inside of blood vessels. When infection occurs, molecular messages are transmitted amongst the white cells and between white cells and edothelium, to activate the immune cells to pass out of the blood vessels and mount a defence. Unfortunatley, the activation system sometimes goes awry, resulting in inflammatory or allergic disease, such as arthritis or asthma. This team of researchers from the Hanson Institute in Adelaide, combining expertise in molecular and cell biology, protein chemestry, structual biology and animal models, has been working together for over 10 years, investigating the molecular mechanisms involved in controlling the formation and activities of blood vessels and white blood cells. This program seeks to further that understanding, and to develop drugs that have the potential of ameliorating the inflammatory condition.

Funding Amount $AUD 4,928,323.53

Funding Scheme Programs

Notes Program Grant