grant

The Leucine Rich Repeat Kinase 1 and 2 Genes are Modulators of Alternative Splicing - Implication for Neurodegeneration [ 2008 - 2011 ]

Also known as: Genes that control alternative splicing in neurodegeneration

Funded by National Health and Medical Research Council
Managed by The University of New South Wales
Managed by University of New South Wales
Provided by   National Health and Medical Research Council

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/510218]

Researchers: A/Pr John Kwok (Principal investigator)

Brief description Alzheimer's disease (AD) and Parkinson's disease (PD) are the two common causes of dementia and neurodegeneration. Through positional cloning, we have identified the leucine rich repeat kinase (LRRK1) 1 gene as a modulator of alternative splicing. We have subsequently shown that its homologue, LRRK2 has a similar biological activity. We propose to study the the genetic and biochemical role of LRRK1 and LRRK2 in neurodegeneration in terms of its effect in splicing.

Funding Amount $AUD 583,809.91

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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270210 | Alzheimer's disease | Biochemistry and molecular biology | Degenerative diseases of the CNS | Gene regulation | Molecular basis of disease | Molecular neuroscience | Parkinson's disease | susceptibility genes |
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