Research Grant
[Cite as https://purl.org/au-research/grants/nhmrc/510218]Researchers: A/Pr John Kwok (Principal investigator)
Brief description Alzheimer's disease (AD) and Parkinson's disease (PD) are the two common causes of dementia and neurodegeneration. Through positional cloning, we have identified the leucine rich repeat kinase (LRRK1) 1 gene as a modulator of alternative splicing. We have subsequently shown that its homologue, LRRK2 has a similar biological activity. We propose to study the the genetic and biochemical role of LRRK1 and LRRK2 in neurodegeneration in terms of its effect in splicing.
Funding Amount $AUD 583,809.91
Funding Scheme NHMRC Project Grants
Notes Standard Project Grant
- nhmrc : 510218
- PURL : https://purl.org/au-research/grants/nhmrc/510218