L-amino acid sensing by the extracellular calcium-sensing receptor: molecular, cellular and in vivo studies [ 2001 - 2003 ]

Research Grant

Researchers: Prof Arthur Conigrave (Principal investigator) ,  Arthur David Conigrave (Managed by) ,  Professor Arthur Conigrave (Managed by)

Brief description Recent work by Dr Conigrave and colleagues demonstrates for the first time that protein and calcium metabolism are linked at the molecular level by the widely distributed calcium-sensing receptor. The project will aim to demonstrate the physiological significance of this finding by testing whether L-amino acids, the building blocks of body protein, exert receptor-dependent control over the secretion and blood levels of hormones that regulate body calcium levels. It will further test the hypothesis by determining whether amino acids exert receptor-dependent control over the proliferation of bone forming cells and urinary excretion of calcium.

Funding Amount $AUD 362,545.90

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant