grant

KYNURENINE PATHWAY METABOLOMIC PROFILING IN THE PROGRESSION OF MULTIPLE SCLEROSIS: DEVELOPMENT OF NOVEL BIOMARKER TO ASSESS DISEASE SEVERITY AND THERAPEUTIC REGIMEN [ 2012 - 2014 ]

Also known as: Kynurenine pathway in multiple sclerosis

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/1031080]

Researchers: Prof Gilles Guillemin (Principal investigator) ,  Dr Chai Lim Prof Bruce Brew

Brief description A metabolic process known as the kynurenine pathway (KP) has been found to be dysregulated in multiple sclerosis (MS) patients. We are currently investigating which components of the KP is impaired that put MS patients in jeopardy. Next, we aim to use specific drugs known to manipulate the KP in order to rectify the impairment and stop MS. Outcome of this study may potentially lead to discovery of new biomarkers to assess severity of MS progression and also novel therapeutic regimen.

Funding Amount $AUD 450,750.92

Funding Scheme Project Grants

Notes Standard Project Grant

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