grant

KLK4 is a master regulator of tumour microenvironment remodelling in prostate cancer and bone metastasis [ 2011 - 2015 ]

Also known as: The PSA-related enzyme, KLK4, is a master regulator of tumour spread in prostate cancer and the associated bone metastasis

Funded by National Health and Medical Research Council
Managed by Queensland University of Technology
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1010141]

Researchers: Prof Judith Clements (Principal investigator) ,  A/Pr Jonathan Harris ,  Prof Christopher Overall ,  Prof Colleen Nelson ,  Prof Dietmar Hutmacher
View all 7 related researchers

Brief description The current biomarker for prostate cancer, PSA, belongs to a large family of related proteins called KLK enzymes. We have evidence that one of these enzymes, KLK4, regulates many different pathways involved in tumour spreading especially to bones. This project will determine the specific components involved with a view to finding better biomarkers of tumour spread and bone metastasis and designing better treatments for these aspects of the disease.

Funding Amount $AUD 596,305.64

Funding Scheme Project Grants

Notes Standard Project Grant

Click to explore relationships graph
Help

Related Organisations

Related People

Subjects
Cancer Cell Biology | Medical and Health Sciences | Oncology and Carcinogenesis | bioinformatics | biomarkers | bone metastasis | cancer biology | cancer prognosis | kallikreins | men's health | prostate cancer | proteomics | therapeutic target |
Identifiers
Viewed: [[ro.stat.viewed]]
Saved to MyRDA Save to MyRDA