Klf5 function in normal and leukaemic haemopoiesis [ 2010 - 2012 ]

Research Grant

Researchers: Prof Richard D'Andrea (Principal investigator) ,  A/Pr Ian Lewis ,  Prof Charles Mullighan ,  Prof Nancy Jenkins

Brief description Acute Myeloid Leukaemia (AML) is a devastating disease that affects both children and adults. New treatments that target particular genetic abnormalities are urgently needed. We have identified KLF5 as a gene that may control blood cell maturation. In AML patient samples we have found alterations of the KLF5 gene that may suppress its activity and contribute to the formation of leukaemia. These leukaemias may be good candidates for treatment with new drugs called methyltransferase inhibitors.

Funding Amount $AUD 609,924.75

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant