KLF1 regulatory networks in health and disease [ 2012 - 2014 ]

Research Grant

Researchers: Prof Andrew Perkins (Principal investigator) ,  Dr Timothy Bailey

Brief description We will investigate how the master control gene, Kruppel-like factor 1, orchestrates production of red blood cells. We will use genetic and cell biology approaches to determine exactly how this factor interprets the genome blueprint in a cell specific manner. We will also determine how mutations in KLF1 cause human diseases such as congenital dyserythropoietic anemia and hereditary persistence of fetal haemoglobin. This has implications for reactivation of HbF in adults with sickle cell disease.

Funding Amount $AUD 610,275.35

Funding Scheme Project Grants

Notes Standard Project Grant