[Cite as http://purl.org/au-research/grants/nhmrc/GNT1091011]
Dr Phurpa Wangchuk
Brief description This project will harness the unique ability of hookworm small molecules (<10 kDa) to modulate inflammation, and exploit these properties to develop novel modalities to treat inflammatory bowel diseases, using millennia of host-parasite coevolution as a guide. The excretory/secretory and somatic extracts will be assessed for their anti-inflammatory properties using TNBS mouse model. Compounds will be separated using HPLC and identified using MS and NMR spectroscopy.
Funding Amount $309,436.00
Funding Scheme Early Career Fellowships
Peter Doherty Biomedical ECF