Research Grant
[Cite as http://purl.org/au-research/grants/nhmrc/1044542]Researchers: Prof Ashley Bush (Principal investigator) , A/Pr David Finkelstein , Dr James Duce
Brief description We recently discovered a novel relationship between the Alzheimer’s amyloid precursor protein (APP) and tau, and that both proteins play a role in regulating iron levels in the brain. We predict that a loss or multiple failures in these iron-regulating systems could foster a toxic iron accumulation in brain, leading to the development of diseases with dementia such as Alzheimer’s and Parkinson’s diseases. We hope to gain a better understanding of their mechanism of action and propose that this pathway is a target for therapeutic intervention.
Funding Amount $AUD 843,352.79
Funding Scheme Project Grants
Notes Standard Project Grant
- PURL : http://purl.org/au-research/grants/nhmrc/1044542
- nhmrc : 1044542