grant

Ion channels underlying inflammatory and post-inflammatory visceral mechanical hypersensitivity [ 2011 - 2014 ]

Also known as: Mechanisms of visceral mechanical hypersensitivity

Funded by National Health and Medical Research Council
Managed by University of Adelaide
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1008100]

Researchers: A/Pr Stuart Brierley (Principal investigator) ,  A/Pr Grigori Rychkov ,  Prof Ashley Blackshaw

Brief description Inflammation causes tissue damage that triggers ion channels within sensory nerve fibres to produce greater signals in response to mechanical events, causing acute pain. In chronic pain, although the inflamed tissue has healed, sensory nerve fibres fail to "reset" back to normal. Often chronic pain is more severe than acute pain. This project will identify which ion channels are responsible for signalling acute and chronic visceral pain, explaining why sensory nerve fibres fail to reset.

Funding Amount $AUD 453,439.09

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
Medical and Health Sciences | Neurosciences | Sensory Systems | gastrointestinal symptoms | inflammation | inflammatory bowel disease (IBD) | ion channels | irritable bowel syndrome (IBS) | pain | pain mechanisms | sensory function | sensory neurons | visceral afferents |
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