Investigation of steroidogenesis as a mechanism of castration resistance in human prostate cancer [ 2012 - 2015 ]

Research Grant

Researchers: Dr Niall Corcoran (Principal investigator) ,  Dr Phillip Parente ,  Prof Anthony Costello ,  Prof Christopher Hovens ,  Prof Martin Gleave

Brief description Prostate cancer is critically dependent upon continued testosterone stimulation, even when the disease becomes resistant to existing hormonal therapies that suppress serum levels. The source of this testosterone is currently unclear. This study aims to identify the site of testosterone synthesis in patients with prostate cancer, and determine the relevance of continued testosterone signalling in patients treated with 'super castrating' hormonal therapy.

Funding Amount $AUD 419,076.33

Funding Scheme Project Grants

Notes New Investigator Grant