Investigation of regulators that control the pro-survival molecule MCL1 and its stabililty in lymphoma and myeloma cells [ 2014 - ]

Research Grant

Researchers: Dr Michael Low (Principal investigator)

Brief description B cell malignancies are common and in many cases result in mortality. The BCL-2 family protein MCL-1 has been shown to be over-expressed in many B cell malignancies. However, the regulation and biology of MCL-1 in these cancers remains largely unknown. We aim to define mechanisms that control regulation of MCL-1 expression in cancer cells at the transcriptional and protein level and hence identify new therapeutic targets.

Funding Amount $137,825.00

Funding Scheme Postgraduate Scholarships

Notes Medical/Dental Postgraduate Scholarship