Investigation of processed snoRNAs as cryptic regulators of the imprinted Prader-Willi syndrome locus [ 2013 - 2016 ]

Research Grant

Researchers: Dr Ryan Taft (Principal investigator) ,  Prof Ernst Wolvetang (Principal investigator) ,  Dr Guy Barry ,  Prof Merlin Butler

Brief description Prader-Willi syndrome (PWS) is a devastating disorder whose symptoms include intellectual disability and compulsive eating. PWS occurs when a piece of the genome is mistakenly deleted, but why this DNA is important is still not understood. Our data indicate that the deleted DNA encodes a suite of previously hidden genetic elements, and here we proposed using the latest high-throughput DNA and RNA sequencing and stem cell technologies to finally unravel this mystery.

Funding Amount $AUD 673,976.79

Funding Scheme Project Grants

Notes Standard Project Grant