Investigation of the localisation, transport and vaccine potential of group A streptococcal cell surface proteins. [ 2006 - 2008 ]

Also known as: Developing new group A streptococcal vaccines.

Research Grant

[Cite as]

Researchers: Prof Mark Walker (Principal investigator) ,  Dr John Aquilina Dr Malak Kotb Prof Gurshuran Chhatwal Prof Victor Nizet

Brief description Streptococcus pyogenes (group A streptococcus; GAS) is a bacterium that causes human skin and throat infections as well as highly invasive diseases including necrotising fasciitis. Additionally, serious sequeale, including rheumatic fever and acute glomerulonephritis, may result following repeated infection. We have recently examined the GAS cell wall and identified 23 proteins that are surface exposed, 20 of which are novel. We hypothesise that a number of these surface exposed proteins represent candidate vaccine antigens capable of conferring protective immunity. We therefore propose to examine these surface proteins as components of experimental vaccines against GAS.

Funding Amount $AUD 505,523.48

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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