Investigation into the intervention of arterial thrombosis and atherosclerosis using shear sensitive nanoparticle drug delivery [ 2015 - 2018 ]

Research Grant

Researchers: Dr Erik Westein (Principal investigator) ,  A/Pr Andrew Murphy

Brief description In this project we aim to provide a targeted therapy that inhibits atherosclerosis, in-stent restenosis and thrombosis; pathologies characterized by high shear stress due to a reduction in the vessel lumen. We will apply microfluidic technology to characterize lipid nano-capsules that are tagged with antibodies against activated platelets or VCAM-1, loaded with anti-platelet or immune suppressive drugs and are prone to rupture specifically under high shear stress conditions.

Funding Amount $AUD 462,601.41

Funding Scheme Project Grants

Notes New Investigator Grant