Investigation of dysfunction of SIGMAR1 in transgenic mouse models, a novel gene implicated in neurodegeneration [ 2011 - 2013 ]

Research Grant

Researchers: A/Pr John Kwok (Principal investigator) ,  A/Pr Ian Blair ,  Dr Carol Dobson-Stone ,  Prof Peter Schofield

Brief description At present, there are no effective therapies for frontotemporal dementia or motor neuron disease. We have identified the SIGMAR1 gene as having a crucial role for these diseases. More importantly, there are therapeutically relevant small molecule drugs that are known to modulate the activity of this gene. We aim to determine the efficacy of pharmacological modulation of Sigma-1 receptor activity in mouse models of dementia.

Funding Amount $AUD 492,119.33

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant