Investigation of Dok2 and Dok1 adapter proteins, in the negative regulation of integrin aIIbb3 platelet signalling. [ 2008 - 2010 ]

Research Grant

Researchers: Dr Sascha Hughan (Principal investigator) ,  Dr Warwick Nesbitt

Brief description Blood platelets play a key role in blood clot formation, prevention of bleeding and are the principal elements contributing to thrombosis leading to heart attack and stroke. Numerous studies have defined pathways promoting platelet activity, however less is known about their negative regulation. In this grant we will examine the role for proteins, Dok2 and Dok1, in the negative regulation of platelets, hoping this leads to development of novel therapeutics for prevention of cardiac disease.

Funding Amount $AUD 446,831.64

Funding Scheme NHMRC Project Grants

Notes New Investigator Grant