grant

Investigation of cellular abnormalities and synapse formation in DOCK8 immunodeficiency [ 2012 - 2015 ]

Also known as: Investigating DOCK8 immunodeficiency

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1022922]

Researchers: Dr Katrina Randall (Principal investigator) ,  The Australian National University (Managed by)

Brief description Why do some people get allergies? Or serious infections? To investigate this we will study mice and humans with a mutation in the DOCK8 gene. People with mutations in the DOCK8 gene get Hyper-IgE Syndrome and develop severe viral infections of the skin as well as allergic disease. By investigating how DOCK8 works in the cells of the immune system, we hope to understand why these infections and allergies occur and find out why these problems can also happen in those without this specific genetic defect.

Funding Amount $AUD 318,284.26

Funding Scheme Project Grants

Notes New Investigator Grant

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