Investigating the use of metformin for the prevention of endometrial cancer [ 2014 - 2018 ]

Research Grant

Researchers: Prof Susan Davis (Principal investigator) ,  Kristy Brown ,  Prof Robin Bell

Brief description Endometrial (uterine) cancer affects approximately 3% of women. Obesity and oestrogen exposure are risk factors for this cancer. A novel approach to prevent endometrial cancer would be to oppose the effects of insulin and oestrogen on endometrial cell growth. This study will investigate whether metformin, commonly used to treat diabetes, blocks cellular pathways by which oestrogen and insulin stimulate endometrial cell growth, and thus evaluate the possibility that metformin might be useful in preventing endometrial cancer.

Funding Amount $AUD 676,755.07

Funding Scheme Project Grants

Notes Standard Project Grant