grant

Investigating the role of SERPINB6 in cochlear function and deafness [ 2012 - 2014 ]

Also known as: Understanding a novel mutation that causes deafness

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1019941]

Researchers: Dr Dion Kaiserman (Principal investigator) ,  Dr Justin Tan

Brief description In 2010 a novel genetic mutation was identified that causes progressive hearing loss in humans, however, it was not established why this mutation leads to the disease. We propose that the mutation renders cells of the inner ear more susceptible to death caused by noise trauma. We will investigate this in a mouse model of the human condition. This could lead to the development of therapies that prevent hearing loss.

Funding Amount $AUD 570,803.41

Funding Scheme Project Grants

Notes Standard Project Grant

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