grant

Investigating the role of the NR4A nuclear receptor family in melanocyte function and tumorigenesis [ 2010 - 2012 ]

Also known as: Understanding NR4A gene function in melanocyte and melanoma cells

Funded by National Health and Medical Research Council
Managed by The University of Queensland
Managed by University of Queensland
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/631510]

Researchers: Dr Aaron Smith (Principal investigator) ,  A/Pr Richard Sturm ,  Prof George Muscat

Brief description Individuals with red hair and fair skin have a considerably greater risk of developing melanoma and non-melanoma skin cancer. Understanding the relationship that genes such as MC1R and NR4As have to skin functions such as tanning and protection from UV damage, will provide a greater insight into melanoma susceptibility and progression. Furthermore, understanding the role that abnormal NR4A regulation plays in melanoma formation will aid in the identification of new therapeutic targets.

Funding Amount $AUD 555,325.32

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
Biological Sciences | DNA repair | Genetics | Gene Expression (Incl. Microarray and Other Genome-Wide Approaches) | cancer predisposition | cancer-melanoma | cancer: mechanisms of growth, invasion, metastases | gene expression | melanocyte | melanoma | nuclear receptor | ultraviolet radiation exposure |
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