Investigating a novel role for the haemopoietic growth factor receptor, c-Mpl, in regulating shear-dependent platelet adhesive function [ 2014 - 2016 ]

Research Grant

Researchers: Prof Shaun Jackson (Principal investigator) ,  A/Pr Simone Schoenwaelder

Brief description Platelets play a critical role in blood clot formation, with low platelet numbers leading to bleeding while excessive clot formation can cause heart attack and stroke. Platelets must ‘stick’ to injured blood vessels under blood flow (shear). We have discovered that the growth factor, c-Mpl, can regulate shear-dependent platelet sticking by controlling receptor ‘shedding’ from the cell surface. We will investigate how c-Mpl performs this new role, and examine platelet function in patients with myeloproliferative disease who have reduced c-Mpl.

Funding Amount $AUD 570,294.32

Funding Scheme Project Grants

Notes Standard Project Grant