Investigating the impact of coincident modulation of adenosine and glutamate receptors on neuronal activity – implications for CNS drug discovery [ 2017 - ]

Research Grant

Researchers: Dr Karen Gregory (Principal investigator) ,  Dr Andrea Vernall ,  Dr Lauren May

Brief description Dementia in particular Alzheimer's disease, is one of the leading causes of death. There remains a need for new drugs to treat both symptoms and disease progression. Two receptors in the brain, the adenosine A1 (A1AR) and metabotropic glutamate 5 (mGlu5) are suggested to be promising new drug targets for dementia. In order to better develop drugs that target these receptors, we will develop a better understanding of activity of these receptors under conditions of health and disease.

Funding Amount $648,447.00

Funding Scheme Project Grants

Notes Standard Project Grant