grant

Investigating Hippo signalling as a novel cause of muscle disease, and as a target for new interventions to combat frailty [ 2011 - 2013 ]

Also known as: The Hippo signaling pathway in frailty and muscle disease

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1009995]

Researchers: A/Pr Paul Gregorevic (Principal investigator) ,  Prof Kieran Harvey

Brief description We will explore the role of the Hippo signaling pathway in muscle development, repair and remodelling. We propose that this little-known pathway which affects organ development, is key for maintaining healthy muscles, and is affected in muscle wasting. Using gene therapy tools to alter this pathway in models of disease, we intend to clarify the role of Hippo signaling in muscle, and establish whether the pathway can be manipulated to treat physical frailty caused by muscle wasting.

Funding Amount $AUD 460,509.63

Funding Scheme Project Grants

Notes Standard Project Grant

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