Investigating the Cellular Response to Iron-Depletion: The Trilogy of ASK1, Thioredoxin and Ribonucleotide Reductase [ 2012 - 2014 ]

Research Grant

Researchers: Prof Des Richardson (Principal investigator) ,  Dr David Lovejoy ,  Dr Yohan Suryo Rahmanto ,  Prof Clare Hawkins ,  Prof Prem Ponka

Brief description Iron is crucial for many essential biological processes. Recently, we demonstrated that iron-depletion can affects important signalling pathways (e.g., JNK and p38) that play important roles in growth arrest and apoptosis. This study is designed to investigate the cellular and molecular effects of iron depletion which currently remains unclear. The research is crucial for understanding: (1) the effects of iron deficiency and (2) for understanding the effects of iron chelators that are used for treating various diseases.

Funding Amount $AUD 552,572.09

Funding Scheme Project Grants

Notes Standard Project Grant