grant

To investigate how the aggregation of proteins during neuronal injury promotes neurotoxic plasmin formation [ 2010 - 2012 ]

Also known as: Assessing how injured neurons form neurotoxic enzymes - novel ways to improve stroke outcome and treatment

Funded by National Health and Medical Research Council
Managed by Monash University
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/606659]

Researchers: Prof Robert Medcalf (Principal investigator) ,  Dr Andre Samson ,  Prof Stephen Bottomley

Brief description tPA is an enzyme given to patients to remove stroke-causing blood clots but can have harmful effects in the brain. tPA needs a cofactor to function optimally. In the blood, this cofactor is fibrin. However the cofactor that allows tPA to function in the brain is unknown. This project explores a novel cofactor for tPA in the injured brain. We will attempt to block this harmful cofactor in the brain while still allowing tPA to remove clots thereby improving stroke outcome.

Funding Amount $AUD 586,428.38

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
Medical and Health Sciences | Neurosciences | Neurosciences Not Elsewhere Classified | acute ischaemic stroke | cardiovascular disease - stroke | improving outcome and safety for thrombolysis in stroke | neuronal cell death | neuronal injury | plasminogen | protein aggregation | stroke |
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