Intrinsic response of airways to cyclical dilation and elongation in breathing [ 2006 - 2008 ]

Research Grant

Researchers: Prof Howard Mitchell (Principal investigator) ,  A/Pr Lynette Fernandes ,  Dr Peter Mcfawn

Brief description Variations in lung pressures during breathing produce cyclical expansion of the airway tubes. These respiratory movements provide one of the most powerful protective mechanisms for the lung. The protective mechanism fails in asthma so that cyclical expansion of the airway tubes can make breathing more difficult. Current belief is that protective and harmful effects of lung expansion occur by either relaxation or contraction of the muscles lining the airway tubes. Findings from this laboratory suggest that the above dogma needs reconsideration. The project will utilize a novel model of the lung to enable us to determine the mechanisms producing both the protective effect, and in asthmatics the harmful effects of cyclical lung expansion. Once the part of the lung that 'fails' in this aspect of asthma has been detected then therapeutic strategies can be put in place to reverse the defect.

Funding Amount $AUD 355,014.67

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant