How intestinal motility activates sensory pathways [ 2013 - 2015 ]

Also known as: how movements of the gut activate sensory nerve cells

Research Grant

[Cite as]

Researchers: Prof Simon Brookes (Principal investigator) ,  A/Pr Philip Dinning Dr Vladimir Zagorodnyuk Prof Nicholas Spencer

Brief description Pain and discomfort from the gut are common and unpleasant. We understand how gut sensory nerve cells work, at the cellular, molecular and genetic level. However, movement of the gut wall and contents are the major cause of activation of sensory neurons. We know little about which particular patterns of movement cause pain. This is crucial information for accurately diagnosing human gut disorders, for monitoring effectiveness of treatments and for identifying potential new drug targets.

Funding Amount $AUD 555,875.25

Funding Scheme Project Grants

Notes Standard Project Grant

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