The interplay between IL-6 and GVHD on anti-viral and anti-leukaemic immunity [ 2016 - 2018 ]

Research Grant

Researchers: Dr Siok-Keen Tey (Principal investigator) ,  Dr Christopher Andoniou

Brief description Bone marrow transplantation can cure leukaemia but infection, graft-versus-host disease (GVHD) and leukaemia relapse remain challenging problems. We recently completed an early phase clinical study on GVHD prevention using interleukin-6 blockade. Interestingly, the rate of virus reactivation was also lower. This project will use a newly developed mouse model and stored clinical samples to understand the underlying mechanism and whether it also has an impact on anti-leukaemic immunity.

Funding Amount $AUD 502,993.15

Funding Scheme Project Grants

Notes Standard Project Grant