Interleukin 38: Uncoupling Innate Inflammation from Interferons in Lupus [ 2018 - 2021 ]

Research Grant

Researchers: A/Pr Marcel Nold (Principal investigator) ,  Prof Eric Morand

Brief description Systemic lupus erythematosus (SLE) is an incurable autoimmune disease that affects 5 million patients worldwide, mostly young women. Grave multi-organ inflammation and substantial loss of life expectancy render SLE a critical unmet medical need. We found that the immune system protein interleukin 38 disables several signalling pathways essential for SLE progress. We will explore regulation and function of this protein in cells from healthy people and SLE patients and in models of the disease.

Funding Amount $AUD 1,063,350.16

Funding Scheme Project Grants

Notes Standard Project Grant