Integrating biology and medicine to develop 3D-structure guided drug design for treatment of cardiovascular disease [ 1/1/2021 - 12/31/2024 ]

Research Grant

Brief description Calcium channel inhibitors are commonly prescribed for the treatment of heart disorders such as angina, hypertension, arrhythmias and hypertrophic heart disease. This class of drugs is one of the leading causes of drug-related fatalities. The impediment to designing better drugs is a lack of understanding of the 3 dimensional (3D) structure of the calcium channel. We will enable for the first time a 3D structure blueprint for the design of safe and highly selective calcium channel therapeutics.

Funding Amount $978,832

Funding Scheme Ideas Grants

Chief Investigator Prof Livia Hool

Notes Ideas Grants