grant

Insulin-like growth factor binding protein-2 is a crucial activator of aggressive behaviour in cancer cells [ 2011 - 2013 ]

Also known as: Insulin-like growth factor binding protein-2 action in cancer cells

Funded by National Health and Medical Research Council
Managed by Murdoch Childrens Research Institute
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1008062]

Researchers: Prof George Werther (Principal investigator) ,  A/Pr John Price ,  Dr Donald Newgreen ,  Dr Vincenzo Russo

Brief description The insulin-like growth factor (IGF) system, required for normal development and adult life, is often altered in many diseases including cancer. Key regulators of the IGF system are the IGF binding protein (IGFBP) of which IGFBP-2 is the 2nd most abundant. IGFBP-2 may enhance or inhibit the IGFs, but the mechanisms are not clear. This proposal aims to dissect IGFBP-2 action with the ultimate goal to provide knowledge for the development of targeted therapeutic modulators of IGFBP-2 activity.

Funding Amount $AUD 612,885.92

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Clinical Sciences | Endocrinology | Medical and Health Sciences | endocrinology | gene transcription | insulin-like growth factor binding protein (IGFBP) | insulin-like growth factors (IGF) | integrins | neuroblastoma | peptides | signalling pathways | therapeutic antibodies | therapeutic target |
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