How insulin and the insulin-like growth factors bind to their receptors - the key role of the ?-chain C-terminal helix [ 2011 - 2013 ]

Research Grant

Researchers: A/Pr Michael Lawrence (Principal investigator) ,  Dr Colin Ward

Brief description Cancer, Alzheimer’s disease and diabetes are three of the most important health issues facing Australia. Aberrant signalling into the cell interior by the related insulin receptor and Type 1 insulin-like growth factor receptor is implicated in all three of these disease states. Our research is aimed at understanding how these signalling events occur at the atomic level of detail – such knowledge has the potential to contribute to the development of novel therapeutics aimed at treating these diseases.

Funding Amount $AUD 752,712.05

Funding Scheme Project Grants

Notes Standard Project Grant