Innate immune sensing of Proteotoxic Stress [ 5/1/2021 - 4/30/2024 ]

Research Grant

Brief description Cells recycle old components using a system called the proteasome. Some people are born without parts of the proteasome, and they suffer from a disease associated with inflammation. We have identified the molecular trigger for this inflammation. Our findings are also relevant for patients being treated with proteasome inhibitors. In some of these diseases, such as lupus, inflammation can be a side-effect of proteasome inhibitor therapy, and we can now reduce this and make the treatments safer.

Funding Amount $501,390

Funding Scheme Ideas Grants

Chief Investigator Dr Sophia Davidson

Notes Ideas Grants