Innate immune factors regulate steroid-resistant airways hyperreactivity and asthma [ 2008 - 2011 ]

Research Grant

Researchers: Dr Ming Yang (Principal investigator)

Brief description Infection induced asthma is often difficult to manage because of lack of efficacy of steroid treatment. The innate immune system plays an important role in inflammation associated with infection. I have shown that two innate immune factors, IFN-gamma and lipopolysaccharide (LPS), induce airways hyperreactivity that is resistant to steroid therapy in a mouse model. Identification of how this pathway works may help in the treatment of infection induced steroid-resistant difficult to manage asthma.

Funding Amount $AUD 524,456.94

Funding Scheme NHMRC Project Grants

Notes New Investigator Grant