Inhibitors of Siah ubiquitin ligase [ 2008 - 2010 ]

Research Grant

Researchers: Prof David Bowtell (Principal investigator) ,  Dr Jack King-Scott ,  Dr Wynne Aherne ,  Mr Colin House ,  Prof Paul Workman

Brief description Recent evidence suggests that the Siah proteins are involved in sensing low oxygen levels in cells, and subsequently activating processes to help the cell survive under these conditions. Low oxygen conditions occur in cancer and sites of inflammation, suggesting that inhibiting Siah may improve patient outcomes in diseases such as cancer and arthritis. We aim to perform a high throughput screen for drugs that inhibit Siah protein function and to test these in cancer cells.

Funding Amount $AUD 568,452.21

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant