Research Grant
[Cite as https://purl.org/au-research/grants/nhmrc/1022693]Researchers: Prof Raymond Norton (Principal investigator) , Prof Jonathan Baell , Prof Martin Scanlon
Brief description The human enzyme iNOS generates reactive nitrogen species that are required for the intracellular killing of pathogens such as bacteria and parasites. Recently, we showed that the SPSB proteins are key regulators of this important enzyme, and that interfering with this regulation enhanced the anti-microbial actions of iNOS. This project will develop small molecule inhibitors of the SPSB-iNOS interaction for use as novel anti-infective agents in humans.
Funding Amount $AUD 643,735.34
Funding Scheme Project Grants
Notes Standard Project Grant
- nhmrc : 1022693
- PURL : https://purl.org/au-research/grants/nhmrc/1022693
