Inhibitors of hypoxanthine-guanine-xanthine phosphoribosyltransferase as versatile drugs to treat infectious diseases [ 2018 - 2020 ]

Research Grant

Researchers: A/Pr Luke Guddat (Principal investigator) ,  A/Pr Lieve Naesens ,  A/Pr Michael Edstein ,  Dr Dana Hockova ,  Prof Vicky Avery

Brief description Due to the increase in resistance to many of the frontline drugs to treat bacterial and parasitic infections, there is an urgent need to develop new pipelines for drug discovery against the pathogens that are causative agents of this diseases. This project pioneers the blocking of nucleotide synthesis to develop new drug leads to treat malaria, human tuberculosis, African sleeping sickness, Chagas disease and uropathogenic E.coli infections.

Funding Amount $AUD 766,163.19

Funding Scheme Project Grants

Notes Standard Project Grant