Inhibition of Bone Resorption Increases Skeletal Mechanical Strength by Thickening Trabecular Structures [ 2000 - 2002 ]

Research Grant

Researchers: Prof Howard Morris (Principal investigator)

Brief description This project will identify the basis by which a number of therapies for osteoporosis decrease the risk of bone fractures. Currently at least four classes of these compounds in current use for the treatment of osteoporosis. Some of them have been found to have a very marked beneficial effect by halving the risk of fracture. This study will determine if each of these classes of compounds have the ability to increase the mechanical strength of bone to the same level and if each of these compounds has the same effects on bone structure. Further the effects of stimulating bone formation by subjecting the skeletal to mechanical stress, on the efficacy of each of the therapies will be established. Conversely the effect of aging, which imposes a limitation on bone formation, will be studied.

Funding Amount $AUD 175,648.59

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant