Research Grant
[Cite as https://purl.org/au-research/grants/nhmrc/1026619]Researchers: Dr Julie Mcauley (Principal investigator) , Dr Deborah Middleton , Prof Lorena Brown
Brief description Influenza virus produces a protein of undefined function called PB1-F2. Infection of mice with virus expressing PB1-F2 from virulent strains causes severe lung inflammation, while PB1-F2 from milder seasonal viruses does not. We will examine how PB1-F2 influences virulence of human influenza in the ferret, which exhibits the same illness as humans. This work will help understand the disease severity of newly evolved influenza viruses of humans and the role of PB1-F2 in mediating this.
Funding Amount $AUD 474,718.18
Funding Scheme Project Grants
Notes Standard Project Grant
- nhmrc : 1026619
- PURL : https://purl.org/au-research/grants/nhmrc/1026619
