The influence of alpha actinins on human performance in health and disease [ 2008 - 2011 ]

Research Grant

Researchers: Prof Kathryn North (Principal investigator) ,  Dr Nan Yang ,  Dr Stewart Head ,  Prof Edna Hardeman ,  Prof Peter Gunning

Brief description We have identified a common genetic variation that results in absence of the fast muscle fibre protein, a-actinin-3, in over 1 billion people worldwide. Loss of a-actinin-3 influences elite athletic performance and skeletal muscle function in the general population by altering efficiency of muscle metabolism. We will now study mice and humans to determine how a-actinin-3 deficiency influences normal muscle function with age, response to exercise and the severity of human muscle disease.

Funding Amount $AUD 480,989.35

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant