grant

The influence of a-actinin-3 on muscle structure, metabolism, performance and response to diet and disease [ 2011 - 2013 ]

Also known as: The effects of a common genetic variant on human health and disease

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1002033]

Researchers: Prof Kathryn North (Principal investigator)

Brief description We have identified a common genetic variant that results in absence of the fast muscle fibre protein a-actinin-3 in more than one billion humans worldwide. Loss of a-actinin-3 influences elite athletic performance, muscle bulk and strength in the general population, response to diet and exercise, and susceptibility to developing type 2 diabetes. We will now study mice and humans to determine how this gene influences variations in human performance, metabolism and severity of muscle disease.

Funding Amount $AUD 624,355.48

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Identifiers
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ACN 633 798 857