Inflammation, genes and atherosclerosis [ 2002 - 2004 ]

Research Grant

Researchers: Prof Joseph Hung (Principal investigator) ,  Dr Caroline Chapman ,  Prof John Beilby ,  Prof Peter Thompson

Brief description Atherosclerotic vascular disease cause considerable morbidity, mortality and use of health services in Australia. Current known risk factors explain approximately half of all cardiovascular diseases. The search for new risk factors is therefore a high priority. Evidence suggests that chronic inflammation is closely involved in the process of atherosclerosis and its clinical complications. This study aims to determine if sensitive serum markers of inflammation and gene-environment interactions that affect inflammation will predict the extent and progression of carotid atherosclerosis in an Aboriginal and a non Aboriginal community population and in patients with premature coronary heart disease. This study should provide a greater understanding of the mechanisms involved in the development and progression of atherosclerosis. It is likely that we will find that some inflammatory markers and candidate gene polymorphisms will help identify individuals at increased cardiovascular risk, and who require earlier treatment to prevent disease. In particular, it would focus on preventive therapies that reduce atherosclerosis through anti-inflammatory targets. This study represents a crucial step towards improving our understanding of the aetiology of cardiovascular diseases, and in developing new ways to prevent heart disease and stroke. Progress in these areas will likely have significant public health benefits

Funding Amount $AUD 287,970.00

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant